Ergogenics   [Definitie:] "An ergogenic aid is any substance or phenomenon that enhances performance." (Wilmore and Costill)   Nieuwsbrief over doping, supplementen, voeding en training
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2 2 - 0 2 - 2 0 0 5 Amphetamine-induced aggression is enhanced in rats pre-treated with the anabolic androgenic steroid nandrolone decanoate Pia Steensland, Mathias Hallberg, Anna Kindlundh, Claudia Fahlke, Fred Nyberg Department of Pharmaceutical Biosciences, Division of Biological Research on Drug Dependence, Uppsala University, Box 591, SE-751 24 Uppsala, Sweden; Department of Psychology, Goteborg University, P.O. Box 500, SE-405 30 Goteborg, Sweden Steroids, (2005). Abstract Aggression is one of the most commonly reported psychiatric side effects among anabolic–androgenic steroids (AAS) users. Furthermore, anecdotal stories say the aggression is even more profound when a current, or former, AAS-user consumes other drugs of abuse such as amphetamine and alcohol. In the present study, we examined the effect of amphetamine on defensive reactivity and defensive aggression in Sprague–Dawley rats after chronic AAS treatment (daily intramuscular [i.m.] injections with 15 mg/kg nandrolone decanoate [ND] for 14 days). Defensive reactions in rodents occur in response to a real threat, but also to perceived provocation, for example, elicited by innocuous stimuli as reaction towards the experimenter. The defensive reactivity and aggression test employed in this study evaluates each rat’s reaction towards four different stimuli (I: approach of a rod; II: startle to an air puff; III: poking with a rod at the flanks, and IV: capturing with a gloved hand) at two different occasions. [Tabel] Immediately following the ND treatment period, no change in the defensive response was found. Nevertheless, an amphetamine challenge given 3 weeks after the last ND or vehicle injection induced a marked increased defensive aggressive response in the ND, compared to vehicle-pre-treated rats. Individual scores in the stimuli IV (capturing with a gloved hand) 3 weeks after the pre-treatment of nandrolone decanoate (ND) or vehicle (controls) (a) are animals receiving saline and (b) are individual scores of animals receiving an amphetamine challenge. Both ND- and vehicle-pre-treated rats receiving amphetamine were found to be more aggressive than comparable groups receiving a saline injection. It can be concluded that pre-treatment with ND modulates the behavioral response to amphetamine and induces long lasting changes in the behavioral response.

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