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19-10-2004
Anabolen mild verslavend
Overzichtsartikel vergelijkt verslavende werking androgenen met die van nicotine. Meest opvallend: de dosering lijkt
er niet toe te doen, amfetamine versterkt de impact van anabolen op de hersenen en als je proefdieren zelf hun inname
testosteron laat bepalen zijn er altijd een paar liefhebbers die zichzelf doodspuiten.
(Physiol Behav. 2004 Nov 15;83(2):279-289.)
[Meer]
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Na pro-Bush-toespraak stond Schwarzenegger twee weken droog (The Times October 20, 2004)
"Arnold Schwarzenegger told a crowd of 1,000 people in California, saying that his much-praised speech to the
Republican Party convention prompted his fiercely Democratic wife to deny him sex for a fortnight. Mr Schwarzenegger’s
speech to the New York convention crowd brought the house down, in spite of a bizarre section praising the disgraced
President Nixon.
Asked how the speech in support of President Bush went down at home, the Governor of California
replied, “Well, there was no sex for 14 days”, and after a pause added that “everything comes with side-effects”."
Kunstenaar met electroden in zijn spieren geeft gastcollege Lichaamsverandering (Wisconsin State Journal October 19, 2004) [offline]
Docente Linda Hogle was kennelijk uitgekeken op de colleges over anabole steroïden en heeft nu He's Stelarc uitgenodigd.
Hij heeft electroden in zijn spier waarmee anderen kunnen bepalen hoe hij beweegt. En hij heeft een derde oor, dat geen
geluid hoort maar geluid maakt. Meer over Stelarc vind je [hier].
Solbar lanceert soja-flavonoïden-extract (nutraingredients.com)
Quest zegt dat het geen informatie doorspeelde aan Balco (New York Daily News)
'Onze procedure is waterdicht', aldus Quest.
Jonge ratten krijgen beetje meer spier door chroompicolinaat (J Trace Elem Med Biol. 2004;18(1):33-9.)
Meer over chroom vind je [hier].
Explosie Creutzfeldt-Jakob in VS (Daily Freeman 10/15/2004)
Twee explosies, eigenlijk. De Amerikaanse regering onderzoekt een uitbraak in Ulster County. Er is een andere uitbraak
onder werknemers van de Garden State Race Track, maar die hebben de media wel zo verschrikkelijk opgeklopt! Van de
zeventien gevallen waren er maar elf die echt iets met de prionziekte te maken hadden, aldus de overheid. Gaat u maar
weer rustig slapen, meneer.
18-10-2004
Na krachttraining is metabolisme spiercel 72 uur verhoogd
Minimaal. 'A single RE bout resulted in increased levels of mRNA for IGFBP4 (84%), MyoD (83%), myogenin (~3-fold), cyclin-D1 (50%),
p21-Waf1 (16-fold) and a transient decrease in IGF-I mRNA (46%). A temporally conserved, significant, correlation between
Myogenin and p21 mRNA was observed (r=0.70, p<0.02).'
(J Appl Physiol. 2004 Oct 1)
Fruit, vitamine C vermindert kans op tegen maagkanker, vitamine E verhoogt de kans (EurekAlert)
Weer een stuk van de Alpha-Tocopherol, Beta-Carotene Cancer Prevention (ATBC) Study afgerond.
Ook gamma-tocoferol geassocieerd met verhoogde kans.
'Via het calcium in de voeding telt het lichaam de calorieën' (Science News Week of Oct. 16, 2004; Vol. 166, No. 16)
Science News over de evolutionaire verklaring voor Michael Zemels theorie over de slankmakende werking van calcium.
"The Tennessee researchers have been investigating the genetics of vitamin D's complex action on energy metabolism.
It starts when 1,25-D opens a channel in the outer membrane of fat cells, allowing calcium to pour in. This does
two things, Zemel has found.
In the nucleus of these cells, the calcium flood turns on a gene called fas, for fatty-acid synthase, which
triggers the production of a key enzyme responsible for making more body fat out of simple sugars. In addition,
Zemel finds, the intracellular calcium inhibits the biochemical machinery responsible for both the breakdown of
fat cells and fat burning.
"Putting all of these elements together," he says, "you find that when you don't have enough calcium in your diet
. . . the end result can be bigger, fatter fat cells."
Moreover, 1,25-D inhibits the activation of a gene called UCP-2 (for uncoupling protein 2). Explains Zemel,
the protein this gene makes "was originally discovered as one that . . . makes us less efficient at using our
energy." In dieters, it means that cells burn fewer calories and store more of them as fat.
The Tennessee researchers have investigated how this happens. One thing that the protein from an expressed UCP-2
gene normally does is regulate the orderly death of fat cells. It targets them for disposal by the body's housekeeping
cells, a process that also carries away any fat the cells may have been holding. However, Zemel told Science News
Online, "when you suppress UCP-2 with a low-calcium diet or increases in 1,25-D, your body won't be able to do as
good a job at killing off your big old fat cells." On the other hand, boosting the diet's calcium content will
suppress the 1,25-D in fat cells, he points out, "which will allow UCP-2 expression to proceed normally . . .
and help you kill off those big old fat cells, again."
Although any calcium source will do—even supplement pills—Zemel's team has shown in a series of studies that
"dairy products are more effective than plain calcium" at suppressing 1,25-D concentrations in fat cells. It
turns out, he says, that "there are other components in dairy [foods] that act synergistically with the calcium
to inhibit fat synthesis and augment fat breakdown." One essential amino acid that appears to play an important
role is leucine, he says. It's an agent his team will be focusing on in future studies."
Wij blijven moeite hebben met die man...
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[Definitie:] "An ergogenic aid is any substance or phenomenon that enhances performance."
(Wilmore and Costill) 
